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Mulshine, James
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overview Other Appointments: Dean, Rush Graduate College (Acting) Vice President, Rush University Medical Center Overview: I have worked on translational research in lung cancer including prevention and biological-based biomarker development with multiple papers and patents related to this work over the last thirty five years. My primary interest has been in the management of early lung cancer. I have served on and chair a number of national and international research advisory boards co-chaired a panel to prioritize development of all relevant biomarkers used in the SPORE program in 2003. I started and led the Upper Aerodigestive Tumor Biology Faculty in the NCI Intramural Program. I have also been involved in technology development issues for many years and served on the NIH Director’s Tech Transfer Subcommittee for nine years while in Bethesda to provide advice on the approval of CRADAs for the intramural NIH programs. Have served as Associate Provost for Research at Rush University from 2005-2015, Acting Dean of the Rush Graduate College from 2012 to the present. Over much of that time, I had the lead responsibility for developing the appropriate infrastructural foundations for biomedical research and education at Rush and worked with the faculty to sustain a productive environment for research and faculty development. Initially my capacity as Associate Provost for Research, I have worked with Dr. Josh Jacobs and the leadership of the Rush research community as we have established a CTSA-like infrastructure funded by Rush institutional support. We worked with the leadership of the ITM over the last 5 years as an affiliate member and have harmonized our research infrastructure and key functions with the corresponding ITM processes. We are now well positioned to join in ITM 2.0 as a fully functional and complementary partner to University of Chicago in achieving the new vision and goals outlined in the current submission. This joint CTSA submission builds on the productive legacy of the PCORI collaboration in CAPriCORN which was led initially by David Meltzer of U of C and now by the Raj Shah of Rush. Other established areas of Rush/ University of Chicago are multiple but involvement in the community research consortium, C3 and the outcomes research consortium, Chicago Learn are two excellent examples of the ongoing success of the U of C/ Rush collaborations. Now over the last several years I have worked as the Acting Dean of the Graduate College and in that capacity have been involved in the planning of the training and mentoring activities proposed in the new CTSA application. Through considerable Rush institutional investment, we bring a totally reengineered Graduate college curriculum for translational research to the new ITM 2.0 effort. I have had a series of roles with ITM 1.0 and have worked to integrate the efforts of the ITM 2.0 with CAPriCORN in relevant setting in collaboration with Dr. Richard Kennedy by cross- walking the governance documents for the PCORI funded, CAPriCORN and the latest NCATS funding opportunity announcement to minimize administrative barriers to complementary activities. In my leadership role in the Graduate College at Rush, I have been responsible for a complete overhaul of the laboratory-based, PhD and Masters programs including implementing a new and sustainable funding model for Rush to greatly enhance its support of translational science PhD education. Supported by the medical bioinformatics faculty at Rush, we have introduced a new rapid learning/ big data course into the Masters of Sciences in Clinical Research curriculum to help our students in the transition to a population healthcare model. We co-developed with the other Chicago AMCs, a recent professional development forum with iBIO for graduate students and post-doctoral fellows in a series that we had previously hosted with the University of Illinois in Chicago. Going forward these events will be sponsored for all Chicago academic medical centers through an inclusive ITM/iBIO collaboration. I continue to maintain a research interest in the area of early lung cancer management especially as it related to quantitative imaging. My ORCID is 0000-0002-4648-9177. My Scopus is 24285376700. My NIH COMMONS name is Jmulshine. Education: BA 1974 College of the Holy Cross, Worcester (Biology) M.D. 1977 Loyola Stritch Medical School, Chicago (Medicine) Residency 1980 Cleveland Clinic Foundation, Cleveland (Internal Medicine) Fellowship 1983 National Cancer Institute, Bethesda (Medical Oncology)
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Academic Article Chemoprevention of head and neck cancer.
Academic Article Lung cancer evolution to preinvasive management.
Academic Article Heterogeneity of cell surface antigen expression of human small cell lung cancer detected by monoclonal antibodies.
Academic Article Fostering chemopreventive agent development: how to proceed?
Academic Article Immunolymphoscintigraphy in patients with lymphoma after subcutaneous injection of indium-111-labeled T101 monoclonal antibody.
Academic Article Autocrine growth factors as therapeutic targets in lung cancer.
Academic Article Identifying prognostic factors in binary outcome data: an application using liver function tests and age to predict liver metastases.
Academic Article Treatment of non-small-cell lung cancer.
Academic Article Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies.
Academic Article Molecular markers in early cancer detection. New screening tools.
Academic Article Insulin-like growth factor expression in human cancer cell lines.
Academic Article Preclinical evaluation of an anti-autocrine growth factor monoclonal antibody for treatment of patients with small-cell lung cancer.
Academic Article Successful anti-cancer drug targets able to pass FDA review demonstrate the identifiable signature distinct from the signatures of random genes and initially proposed targets.
Academic Article Monoclonal antibodies for early cytologic detection of lung cancer.
Academic Article Lack of in vitro synergy between etoposide and cis-diamminedichloroplatinum(II).
Academic Article Monoclonal antibody alpha IR-3 inhibits non-small cell lung cancer growth in vitro and in vivo.
Academic Article Radiographic imaging of bronchioloalveolar carcinoma: screening, patterns of presentation and response assessment.
Academic Article A phase II trial of carboplatin (CBDCA) in small-cell and non-small-cell lung cancer with correlation to in vitro analysis of cytotoxicity.
Academic Article Volume CT for diagnosis of nodules found in lung-cancer screening.
Academic Article Radiologic screening for lung cancer.
Academic Article Combination Therapy of PPARgamma Ligands and Inhibitors of Arachidonic Acid in Lung Cancer.
Academic Article Screening for lung cancer.
Academic Article MDR1 gene expression in lung cancer.
Academic Article Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886.
Academic Article Antibody 624H12, which detects lung cancer at early stages, recognizes a sugar sequence in the glycosphingolipid difucosylneolactonorhexaosylceramide (V3FucIII3FunLc6Cer).
Academic Article Clinical issues in the management of early lung cancer.
Academic Article Tobacco money: up in smoke?
Academic Article Indium-111 T101 monoclonal antibody is superior to iodine-131 T101 in imaging of cutaneous T-cell lymphoma.
Academic Article New molecular strategies for early lung cancer detection.
Academic Article Development of The American Association for Thoracic Surgery guidelines for low-dose computed tomography scans to screen for lung cancer in North America: recommendations of The American Association for Thoracic Surgery Task Force for Lung Cancer Screening and Surveillance.
Academic Article Prospective randomized comparison of high-dose and standard-dose etoposide and cisplatin chemotherapy in patients with extensive-stage small-cell lung cancer.
Academic Article Tobacco control since the 1964 Surgeon General's Report: reflecting back and looking forward.
Academic Article Phenotypically different cells with heterogeneous nuclear ribonucleoprotein A2/B1 overexpression show similar genetic alterations.
Academic Article Lung cancer screening.
Academic Article Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Academic Article Preliminary results for positron emission mammography: real-time functional breast imaging in a conventional mammography gantry.
Academic Article Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer.
Academic Article Screening for lung cancer: in pursuit of pre-metastatic disease.
Academic Article The Liverpool Statement 2005: priorities for the European Union/United States spiral computed tomography collaborative group.
Academic Article Volumes Learned: It Takes More Than Size to "Size Up" Pulmonary Lesions.
Academic Article Clinical significance of the association of the Von Hippel-Lindau disease with pheochromocytoma and pancreatic apudoma.
Academic Article Developing CT image-processing tools to accelerate progress in lung cancer drug development.
Academic Article Early detection of lung cancer.
Academic Article Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines.
Academic Article Peptide structure. Beyond transcriptional events.
Academic Article New approaches to the integrated management of early lung cancer.
Academic Article Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations.
Academic Article Application of high-resolution CT imaging data to lung cancer drug development: measuring progress: workshop IX.
Academic Article A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion.
Academic Article The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups.
Academic Article The International Association Study Lung Cancer (IASLC) Strategic Screening Advisory Committee (SSAC) response to the USPSTF recommendations.
Academic Article The potential contributions of chronic inflammation to lung carcinogenesis.
Academic Article Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction.
Academic Article Effect of gastrin-releasing peptide on the pancreatic tumor cell line (Capan).
Academic Article Lung Cancer Workshop XI: Tobacco-Induced Disease: Advances in Policy, Early Detection and Management.
Academic Article Transferrin dependence of Ga (NO3)3 inhibition of growth in human-derived small cell lung cancer cells.
Academic Article Biochemical characterization of peptide alpha-amidation enzyme activities of human neuroendocrine lung cancer cell lines.
Academic Article NCI-Navy Medical Oncology Branch cell line data base.
Academic Article Issues with implementing a high-quality lung cancer screening program.
Academic Article cDNA expression profiling reveals elevated gene expression in cell clusters overlying focally disrupted myoepithelial cell layers: implications for breast tumor invasion.
Academic Article Moving to the routine management of pre symptomatic lung cancer.
Academic Article Clinical use of a monoclonal antibody to bombesin-like peptide in patients with lung cancer.
Academic Article Purification and characterization of a protein that permits early detection of lung cancer. Identification of heterogeneous nuclear ribonucleoprotein-A2/B1 as the antigen for monoclonal antibody 703D4.
Academic Article Commentary: lung cancer screening--progress or peril.
Academic Article Addressing tobacco use in patients with cancer: a survey of American Society of Clinical Oncology members.
Academic Article A quantitative method for estimating individual lung cancer risk.
Academic Article Evaluation of an interactive science publishing tool: toward enabling three-dimensional analysis of medical images.
Academic Article Surgical considerations with lung cancer screening.
Academic Article Need for uniformity in collection and reporting of data in cancer clinical trials.
Academic Article Considerations in developing successful, population-based molecular screening and prevention of lung cancer.
Academic Article Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression.
Academic Article Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia.
Academic Article Early stage lung cancer--new approaches to evaluation and treatment: conference summary statement.
Academic Article Shared decision making and screening: an ongoing dialogue informed by data.
Academic Article Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas.
Academic Article Lung cancer and inflammation: interaction of chemokines and hnRNPs.
Academic Article Prospects for lung-cancer screening.
Academic Article New developments in lung cancer screening.
Academic Article Epithelial-directed drug delivery: influence of formulation and delivery devices.
Academic Article Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non-small cell lung cancer growth.
Academic Article Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?
Academic Article The early detection of occult lung cancer.
Academic Article Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxia.
Academic Article Lung cancer chemoprevention: moving from concept to a reality.
Academic Article Novel Phenotypic Fluorescent Three-Dimensional Co-Culture Platforms for Recapitulating Tumor in vivo Progression and for Personalized Therapy.
Academic Article Autocrine growth factors in human small cell lung cancer.
Academic Article Lung cancer screening with spiral CT: toward a working strategy.
Academic Article Cytometric validation of immunocytochemical observations in developing lung cancer.
Academic Article Peripheral airway cell differentiation in human lung cancer cell lines.
Academic Article Clinical practice. Lung cancer screening.
Academic Article Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer.
Academic Article Peptide amidating activity in human bronchoalveolar lavage fluid.
Academic Article Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodules.
Academic Article Differential oblique angle spectroscopy of the oral epithelium.
Academic Article Tobacco cessation and control a decade later: American society of clinical oncology policy statement update.
Academic Article Anticancer antibodies for lung cancer.
Academic Article Is the gene expression pattern of lung cancer detected by screening with spiral computed tomography different from that of symptom-detected lung cancer?
Academic Article E-cigarettes and cancer patients.
Academic Article Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers.
Academic Article Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.
Academic Article Peripheral airway cell marker expression in non-small cell lung carcinoma. Association with distinct clinicopathologic features.
Academic Article Lung cancer screening with low-dose CT: more questions than answers--author's reply.
Academic Article Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells: a new approach to early lung cancer detection.
Academic Article Not significant but important.
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Academic Article Correlation of in vitro drug sensitivity testing results with response to chemotherapy and survival: comparison of non-small cell lung cancer and small cell lung cancer.
Academic Article Lung cancer: rational strategies for early detection and intervention.
Academic Article Introduction: Imaging in diagnosis and treatment of lung cancer.
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Academic Article Biomedical imaging archive network.
Academic Article In vivo diagnosis and therapy of human tumors with monoclonal antibodies: selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung.
Academic Article Cytokines and growth factors stimulate hyaluronan production: role of hyaluronan in epithelial to mesenchymal-like transition in non-small cell lung cancer.
Academic Article Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors.
Academic Article Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.
Academic Article Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer.
Academic Article Expression of early lung cancer detection marker: hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer.
Academic Article Early lung cancer detection: approaching the 'tipping point'?
Academic Article Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs.
Academic Article IV international conference on prevention and early detection of lung cancer, Reykjavik, Iceland, August 9-12, 2001.
Academic Article Lessons from considering the cancer landscape.
Academic Article Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors.
Academic Article Glycolipid antigen expression in human lung cancer.
Academic Article Reflections on early cancer control efforts.
Academic Article Diagnostic research: breakout group report.
Academic Article An actuarial analysis shows that offering lung cancer screening as an insurance benefit would save lives at relatively low cost.
Academic Article The correct dose: pharmacologically guided end point for anti-growth factor therapy.
Academic Article Outcome of patients with small-cell lung cancer: effect of changes in staging procedures and imaging technology on prognostic factors over 14 years.
Academic Article RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma.
Academic Article Lung cancer screening: what is the benefit and what do we do about it?
Academic Article An actuarial approach to comparing early stage and late stage lung cancer mortality and survival.
Academic Article Lung cancer screening moving forward.
Academic Article Advancing patient-centric genomic medicine.
Academic Article Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.
Academic Article Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma.
Academic Article Considerations in bringing a cancer biomarker to clinical application.
Academic Article A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line.
Academic Article Lung cancer screening: panacea or pipe dream?
Academic Article Use of high-resolution CT imaging data in lung cancer drug development: measuring progress.
Academic Article The use of volumetric CT as an imaging biomarker in lung cancer.
Academic Article Lung cancer screening: achieving more by intervening less.
Academic Article Considerations in the development of lung cancer screening tools.
Academic Article Solid-phase peptide quantitation assay using labeled monoclonal antibody and glutaraldehyde fixation.
Academic Article Growth factor effects on small cell lung cancer cells using a colorimetric assay: can a transferrin-like factor mediate autocrine growth?
Academic Article Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study.
Academic Article Current issues in lung cancer screening.
Academic Article Lung cancer screening guidelines: common ground and differences.
Academic Article hnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines.
Academic Article Overview: NCI Workshop on Investigational Strategies for Detection and Intervention in Early Lung Cancer.
Academic Article The pharmacology of monoclonal antibodies.
Academic Article Role of the Quantitative Imaging Biomarker Alliance in optimizing CT for the evaluation of lung cancer screen-detected nodules.
Academic Article Platelet-bound IgG in systemic lupus erythematosus with and without thrombocytopenia.
Academic Article Lung cancer: current therapies and new targeted treatments.
Academic Article Implementing computed tomography-based lung cancer screening in the community.
Academic Article Quality assurance and quantitative imaging biomarkers in low-dose CT lung cancer screening.
Academic Article Scientific Advances in Thoracic Oncology 2016.
Academic Article International Association for the Study of Lung Cancer Computed Tomography Screening Workshop 2011 report.
Academic Article Moonshot Acceleration Factor: Medical Imaging.
Academic Article Status of lung cancer screening.
Academic Article One Screening for Ischemic Heart Disease, Lung Cancer, and Chronic Obstructive Pulmonary Disease: A Systems Biology Bridge for Tobacco and Radiation Exposure.
Academic Article Implementation of lung cancer screening in Europe: challenges and potential solutions: summary of a multidisciplinary roundtable discussion.
Academic Article From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later.
Academic Article The International Association for the Study of Lung Cancer Early Lung Imaging Confederation.
Academic Article QIBA guidance: Computed tomography imaging for COVID-19 quantitative imaging applications.
Academic Article Thoracic CT screening: using routinely detectable COPD information.
Academic Article The Long, Slow Road to Lung Cancer Cure.
Academic Article Emphysema Detection in the Course of Lung Cancer Screening: Optimizing a Rare Opportunity to Impact Population Health.
Academic Article The International Association for the Study of Lung Cancer Early Lung Imaging Confederation Open-Source Deep Learning and Quantitative Measurement Initiative.
Academic Article Quantitative imaging workshop XIX: Utilizing quantitative thoracic imaging to optimize population health final summary.
Concept Smoking Prevention
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